COL4A3 Mutation Induced Podocyte Apoptosis by Dysregulation of NADPH Oxidase 4 and MMP-2.

Jun Tong,Qimin Zheng,Xiangchen Gu,Qinjie Weng,Shuwen Yu,Zhengying Fang,Hafiz Muhammad Jafar Hussain,Jing Xu,Hong Ren,Nan Chen,Jingyuan Xie

Kidney international reports（2023）

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摘要

These results indicated that NOX4 might induce podocyte apoptosis through the regulation of MMP-2 in patients with mutations. Our findings provided new insights into the mechanism of ADAS.

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关键词

nadph oxidase,apoptosis,mutation

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