Identification and validation of key biomarkers based on RNA methylation genes in sepsis.

Qianqian Zhang,Xiaowei Bao,Mintian Cui,Chunxue Wang,Jinlu Ji,Jiongjie Jing,Xiaohui Zhou,Kun Chen,Lunxian Tang

Frontiers in immunology（2023）

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摘要

Our study uncovered that dysregulation of RNA methylation genes (m1A, m5C, m6Am, m7G and Ψ) was closely involved in the pathogenesis of sepsis, providing new insights into the classification of sepsis endotypes. We also revealed that five hub RMGs could function as novel diagnostic biomarkers and potential targets for treatment.

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关键词

rna methylation genes,sepsis,key biomarkers

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