SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile.

Jia-Yuan Zhang,Justin P Whalley,Julian C Knight,Linda S Wicker,John A Todd,Ricardo C Ferreira

Genome medicine（2023）

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摘要

SARS-CoV-2 infection causes a prolonged increase in the pro-inflammatory transcriptional status that could predispose post-acute patients to the development of long-term health consequences, including autoimmune disease, reactivation of other viruses and disruption of the host immune system-microbiome ecosystem.

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关键词

COVID-19,SARS-CoV-2,Post-acute sequelae of COVID-19 (PASC),IL-2-induced anti-inflammatory signature,NF-kB,Single-cell multiomics

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