The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4.

Mi Xu,Bingrong Li,Junjun Huang,Rong Jia,Jihua Guo

International endodontic journal（2023）

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摘要

Thus, within the limitations of this study, the data suggest that FTO promotes odontoblastic differentiation during dentine formation by stabilizing RBM4 mRNA to promote RUNX2 exon 5 inclusion.

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关键词

animal model, cell differentiation, dental pulp stem cell(s), dentine, mRNA decay, odontoblast(s)

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