TESOGENASE, An Engineered Nuclease Editor for Enhanced Targeted Genome Integration.

Hangu Nam,Keqiang Xie,Ishita Majumdar,Shaobo Yang,Jakob Starzyk, Danna Lee, Richard Shan,Jiahe Li, Hao Wu

bioRxiv : the preprint server for biology（2023）

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摘要

A reporter Knock-in screening establishes enGager system to identify TESOGENASE editor to improving ssDNA mediated genome integrationMini-TESOGENASEs developed by fusing Cas9 nuclease with novel ssDNA binding motifsmRNA mini-TESOGENASEs enhance targeted genome integration via various non-viral delivery approachesEfficient functional CAR-T cell engineering by mini-TESOGENASE.

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engineered nuclease editor,genome

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