Dynamics of IgG antibody response against Plasmodium antigens among Nigerian infants and young children.

Maternally transferred anti-malarial IgG antibodies rapidly decline during the first 6 months of life, with variations among specific antigens and malaria transmission intensity. From 3-23 months of age, there was a wide range in IgG levels for the blood-stage antigens indicating high individual variation in antibody production as children are infected with malaria. Non- species-specific antigens showed similar patterns in waning immunity and correlation with paired mother's IgG levels compared to antigens.