KMT2C expression and DNA homologous recombination repair factors in lung cancers with a high-grade fetal adenocarcinoma component.

Masaki Suzuki,Rika Kasajima,Tomoyuki Yokose,Eigo Shimizu,Seira Hatakeyama,Kiyoshi Yamaguchi,Kazuaki Yokoyama,Kotoe Katayama,Rui Yamaguchi,Yoichi Furukawa,Satoru Miyano,Seiya Imoto,Aya Shinozaki-Ushiku,Tetsuo Ushiku,Yohei Miyagi

Translational lung cancer research（2023）

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摘要

Cancers containing H-FLAC components showed lower levels of KMT2C and HRR factors than common lung adenocarcinomas, and their levels exhibited a positive correlation. These results support the hypothesis that loss of KMT2C function decreases the expression of the HRR factors in H-FLACs. H-FLACs with low expression may be a good indication for poly (ADP-ribose) polymerase (PARP) inhibitor-based therapy.

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关键词

Fetal adenocarcinoma, KMT2C, lung adenocarcinoma, BRCA1, BRCA2

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