Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau.

Vinay Banka, Andrew Kelleher,Dag Sehlin,Greta Hultqvist,Einar M Sigurdsson,Stina Syvänen,Yu-Shin Ding

Frontiers in nuclear medicine (Lausanne, Switzerland)（2023）

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摘要

We successfully labeled four novel and specifically engineered bispecific antibodies with [F]SFB under mild conditions with a high RCY and purities. This study provides strategies to create brain-penetrable F-18 radiolabeled antibody probes for the selective detection of tau and Aβ aggregates in the brain of transgenic AD mice via PET imaging.

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