Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders.

S S Gangadin, M Germann, L D de Witte, K A Gelderman, R C W Mandl,I E C Sommer

Schizophrenia research（2023）

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摘要

This study demonstrated that C4A was negatively related to - specifically - frontal brain volumes in SSD, but this relation was inverse for HC. The results support the hypothesis of complement-mediated brain volume reduction in SSD. The results also suggest that C4A has a differential association with brain morphology in SSD compared to HC.

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关键词

Schizophrenia, Complement, Inflammation, Brain volumes, Cortical thickness, Cognition

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