The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic activity. Cinnamom Cortex aqueous extract (CCAE) posse s hypoglycemic effect, but there were no active Henccompounde, in this sidentifiedtudy , asth e qqualityuali ty sstandrtand arofd anCCAEd th eto hbeyp ogusedly cine mithec effcinvesigatet of C Cof AE werhypoglycemice inve stigaactivity.ted. Hence, Cinnamaldehydein this s uanddy , thecoumarin qua itasy stheta ndaqualityrd and controlthe hiny pogCCAElyc emwereic effeanalyzedct of Cby CAhighE were iperformancenvesti gatliquided. chromatographyCinnamaldehyde and(HPLC) coumarinmethod. a Thethe resultsquality showedcontrol inthat theCCAE averagewere yieldanalyzed of by extractionhigh was performance10.06%. liquidThe oncenrationchromatography of (HPLC)coumarin methodwas linearThe withresults peak showdarea that rangingthe fromaverage yield0.02-1.00 of mu g/mLextract (ron = was 0.99910 6,06% n = The6) concentration of coumarin was linear with peak area ranging from 0.02-1 00 mu g/mL ( = 0.999 6, = 6) and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of and 1.05-52.50that of mu g/mL cinnamaldehyde(r = 0.999 also7, n = 6). demonstratedThe aaverage good recoverylinear rate elationshipof coumarinwith andpeak area in cinnamaldehydethe range wasof 99.42%1.05-52 50and mu g/mL100.11%, (r 0.999respectively. 7 n The6). The investigtionaverage of recovery hypoglycemirate of coumarineffect andrevealed that cinnamaldehydeCCAE couldwas improve weight loss, lower liver and pancreas indices, improve organ damage caused by diabetes, and lower 99.42% and 100.11%, respectively. The investigation of hypoglycemic effect revealed that CCAE could fasting blood glucose, glycosylated serum protein (GSP) and total cholesterol (TC) levels. The results showed improve weight loss, lower liver and pancreas indices, improve organ damage caused by diabetes, and lower fasing blood gucose, glycosylate serm protein (GSP) and total cholestrol (TC) that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.