Neonatal Nutrition: Evidence-Based Recommendations for Common Conundrums

A silicone containing one cationic quaternary ammonium salt (QAS) and three N-halamine sites in the repeating unit was developed on SiO2 submicron spheres for better antibacterial performance, larger bactericidal area and easier recyclability. Briefly, a precursor (NDAM) with high content of N-halamine was prepared by the amidation reaction. Then, a SiO2@NDA nanocomposite was synthesized. Chlorination of the three imide NH bonds in the repeat unit finalized the synthesis of the bactericidal silicone (SiO2@NDA-Cl). The synthetic steps and products were characterized and the effect of the contents of NDAM in copolymer on antibacterial activity were systematically assayed. The SiO2@NDA-Cl showed higher deactivation abilities against both E. coli and S. aureus compared with their counterparts that contained only one cationic center or one N-halamine. This study has theoretical and practical application value for the development of new antibacterial materials.