Biomimetic redox-responsive prodrug micelles with diselenide linkage for platinum nanozymes augmented sonodynamic/chemo combined therapy of colon cancer

Yuanru Zhao,Jingwen Xu,Yuanyuan Zhang, Feng Wu,Wei Zhao,Runqing Li,Yun Yang,Mingzhen Zhang,Yujie Zhang,Cheng Guo

Chemical Engineering Journal（2023）

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摘要

•DPC@Pt@M possessed redox responsibility and excellent targeting ability.•The Pt nanozyme dropped in the nanomicelles could enhance SDT.•DPC@Pt@M improved the synergetic efficacy of sono-chemotherapeutics.

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关键词

SDT,PTX,Ce6,SOD,POD,CAT,MMP,GSH,ROS,GOD,DC,DP,DC@Pt,Pt,DC@Pt@M,DP@M,DPC@Pt@M,DSeDP-alt-PEG,ICP,1HNMR,FTIR,TMS,CMC,PDI,Dh,TEM,DLS,GSSH,IMS,WBC,LYM,HGB,RBC,NEUT,PLT,ALT,AST,CREA,UREA,CK,LDH 1,ROI

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