Epithelioid Mesothelioma Patients with Very Long Survival Display Defects in DNA Repair.

Monica Ganzinelli,Federica Guffanti,Anna Ianza,Navid Sobhani,Sergio Crovella,Fabrizio Zanconati,Cristina Bottin,Marco Confalonieri,Stefano Fumagalli,Alessandra Guglielmi,Daniele Generali,Giovanna Damia

Cancers（2023）

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摘要

The down-regulation of DNA repair signature in VLS was functionally validated by a lower % of RAD51 and BRCA1-positive tumor cells. If these data can be corroborated in a prospective trial, an easy, cost-effective test could be routinely used to better manage treatment in MPM patients.

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epithelioid mesothelioma patients,long survival display defects,dna,repair

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