Intrinsic functional connectivity among memory networks does not predict individual differences in narrative recall

Individuals differ greatly in their ability to remember the details of past events, yet little is known about the brain processes that explain such individual differences in a healthy young population. Previous research suggests that episodic memory relies on functional communication among ventral regions of the default mode network (“DMN-C”) that are strongly interconnected with the medial temporal lobes. In this study, we investigated whether the intrinsic functional connectivity of the DMN-C subnetwork is related to individual differences in memory ability, examining this relationship across 243 individuals (ages 18-50 years) from the openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset. We first estimated each participant’s whole-brain intrinsic functional brain connectivity by combining data from resting-state, movie-watching, and sensorimotor task scans to increase statistical power. We then examined whether intrinsic functional connectivity predicted performance on a narrative recall task. We found no evidence that functional connectivity of the DMN-C, with itself, with other related DMN subnetworks, or with the rest of the brain, was related to narrative recall. Exploratory connectome-based predictive modeling (CBPM) analyses of the entire connectome revealed a whole-brain multivariate pattern that predicted performance, although these changes were largely outside of known memory networks. These results add to emerging evidence suggesting that individual differences in memory cannot be easily explained by brain differences in areas typically associated with episodic memory function. ### Competing Interest Statement The authors have declared no competing interest.