AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects

•Compared with traditional radiotherapy, FLASH can protect normal tissues and organs as well as reduce side effects.•The obtained platelet cell membrane coating endowed our radiosensitizer TPT specific targeting ability to tumor site.•Novel radiosensitizer TPT was designed to enhance FLASH therapeutic efficacy and prevent tumor recurrence.