Safety and Hemostatic Effectiveness of SURGICEL & REG; Powder in Mild and Moderate Intraoperative Bleeding

This postmarket clinical study evaluated the safety and effectiveness of the novel adjunctive topical hemostat SURGICEL (R) Powder (SURGICEL (R) -P), a powdered form of oxidized regenerated cellulose. In a prospective, open-label, single-arm multicenter trial, adult surgical subjects with mild-to-moderate bleeding for which conventional hemostatic methods were impractical/ineffective were treated with SURGICEL (R) -P. Descriptive analyses included hemostatic success rate at 3, 5, and 10 min, rebleeding and thromboembolic events, SURGICEL (R) -P-related serious adverse events requiring surgical intervention, and SURGICEL (R) -P ease of use (questionnaire). In 8 centers, 103 subjects were enrolled with a median (range) age of 64.0 (33.0-88.0) years. Surgeries were open (53.4%) or laparoscopic/thoracoscopic (46.6%) and mostly urological (37.9%) and abdominal (32.0%) procedures. Bleeding sites included various tissue types, with a median (range) surface area of 4 (0.02-72.0) cm(2). Hemostatic success rates were 77.7%, 87.4%, and 92.2% at 3, 5, and 10 min, respectively. In 7 subjects (6.8%), investigators reverted to standard of care. No safety signals were identified. Two deaths occurred with causes unrelated to SURGICEL (R) -P. Investigators favorably evaluated the ease of use of the SURGICEL (R) -P device. SURGICEL (R) -P is safe and effective in controlling mild-to-moderate bleeding in a broad range of surgical procedures. The trial was registered at as NCT03762200.