Synthesis of Substituted Pyrido[1,2‐a]benzimidazoles by Ruthenium‐Catalyzed C−H Bond Activation and Tandem Cyclization of 2‐Arylimidazo[1,2‐a]pyridines with Iodonium Ylides
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
Ruthenium-catalyzed C-H bond activation and tandem cyclization of 2-arylimidazo[1,2-a]pyridines with iodonium ylides proceed efficiently. For the first time, the easily available iodonium ylides and inexpensive ruthenium complex were employed to synthesize pyrido[1,2-a]benzimidazole derivatives in good yields under simple and easy-to-operate conditions. Several primary mechanism investigations and synthetic applications involving gram-scale preparation, derivatization reactions and the transformation of iodonium ylide generated in situ have also been conducted.
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关键词
C−H activation,2-arylimidazo[1,2-a]pyridines,iodonium ylides,pyrido[1,2-a]benzimidazoles,ruthenium
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