Towards a Science-Based Testing Strategy to Identify Maternal Thyroid Hormone Imbalance and Neurodevelopmental Effects in the Progeny – Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-Ndt-tas)

Stephanie Melching-Kollmuss,Kathrin Bothe,Alex Charlton,Babunilayam Gangadharan,Rashin Ghaffari,Sylvia Jacobi,Sue Marty,Heike-Antje Marxfeld,Elizabeth F. F. McInnes,Ursula G. G. Sauer,Larry P. P. Sheets,Christian Strupp,Helen Tinwell,Christiane Wiemann,Philip A. A. Botham,Bennard van Ravenzwaay

CRITICAL REVIEWS IN TOXICOLOGY（2023）

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Key words

Endocrine disruptor,thyroid modality,adverse outcome pathway (AOP),mode-of-action (MoA),thyroid peroxidase (TPO),sodium-iodide symporter (NIS),deiodinase (DIO),uridine diphosphate glucuronyltransferase (UGT),liver enzyme induction,weight-of-evidence (WoE),extended one-generation reproductive toxicity study (EOGRTS,OECD TG 443),developmental neurotoxicity study (DNT study,OECD TG 426),motor activity,cognitive function (learning and memory)

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