Aldosterone in polycystic ovary syndrome

Objective: Aldosterone was involved in several metabolic disorders. Elevated levels were also reported in polycystic ovary syndrome (PCOS). Objective: to investigate aldosterone and metabolic abnormalities in PCOS at first discovery Design and method: we conducted a case-control study. First diagnosed PCOS patients were included with age and body mass index matched controls. Fasting blood samples were taken at the 3rd day of mezes. Aldosterone was assayed by ELISA DRG kit. The other parameters were dertemined by cobas 6000-Roche. Results: A total of 77 participants were enrolled: 41 PCOS and 35 controls. Aldosterone levels were significantly higher in PCOS. Median value in controls was 160ng/mL. We observed that 70% of aldosterone levels in PCOS were above this median value. Increased aldosterone levels were associated with elevated fasting glucose. Although, There was no significant difference in the prevalence of insulin-resistance, dyslipidemia, obesity, and metabolic syndrome between patients with different aldosterone levels distribution. Conclusions: Elevated aldosterone levels could be the primum movens activating carbohydrate metabolic alterations. Once elevated, aldosterone levels could give evidence of preclinic alterations at an early stage of PCOS.