Online continuous measurement of arterial pulse pressure and pressure waveform using ultrasound

•An image-free ultrasound system includes integrated multi-ultrasound transceiver channel hardware and real-time signal processing software was developed for continuous, non-invasive PP and blood pressure waveform measurement.•The software evaluates local PWV with a low-computation-consuming method using high frame rate ultrasound line, ensuring online presentation of PP and blood pressure waveform in an automated manner.•Comprehensive in vitro and human experiments (20 + 7) demonstrated the accuracy and reliability of this system in measuring PP and blood pressure waveforms.•This work presents a simple, scalable image-free ultrasound blood pressure waveform measurement method, with potential application prospects in the diagnosis and prevention of CVDs.