Highly efficient Ni-catalyzed C-N coupling in alkane solvents

Xiaolin Jiang,Haiyan Hu,Shizhen Zhao, Qin Shi,Mei Wang,Zengyan Zhu,Yuehui Li

MOLECULAR CATALYSIS（2023）

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摘要

•Room-temperature and robust C-N coupling methodology.•Discovered the promoting effect of alkane solvents.•Synthesis of morpholine and pirazine heterocycle derivatives.•Prepared amines showing in vitro antiproliferative activities.

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关键词

C-N coupling,Ni-catalysis,NHC lignad,Alkane solvent,Amine

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