K₂S₂O₈-Mediated Radical Cascade Alkylation/Cyclization of Ynones: Access to Oxoalkyl-Substituted Indenones

A simple and efficient oxidative-promoted radical cascade annulation of ynone derivatives with ketones for the construction of a series of oxoalkyl-substituted indenones in moderate to good yields is described. The control experiment results indicate that the oxidative acetmethylation/arylation of ynone derivatives involves a radical cascade cyclization process. This is an operationally simple and efficient protocol which will be attractive in organic synthesis chemistry.