Iron-catalyzed [4

Jindian Duan,Gaochen Xu,Binsen Rong,Huan Yan,Sai Zhang,Qinghuan Wu,Ning Zhu,Kai Guo

GREEN SYNTHESIS AND CATALYSIS（2021）

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摘要

The iron-catalyzed [4 + 2] annulation of & alpha;,& beta;-unsaturated ketoxime acetates with enaminones has been developed, providing efficient access to highly substituted pyridines in moderate to good yields. Notable features of the present strategy include low-cost catalytic system, simple and mild reaction condition and wide substrate scope. Mechanistic studies reveal that FeCl2 may directly serve as a Lewis acid to activate the & alpha;,& beta;-unsaturated ketoxime acetates for the nucleophilic addition.

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关键词

[4 + 2] annulation,Ketoxime acetates,Enaminones,Pyridines,Iron-catalyzed

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