Sarcodonol A–D from fruiting bodies of Sarcodon imbricatus inhibits HCoV-OC43 induced apoptosis in MRC-5 cells

Hye Jin Yang,Eun-Bin Kwon,Jang-Gi Choi,Wei Li

Bioorganic chemistry（2023）

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摘要

•Four new ergostane-type sterols were isolated from shingled hedgehog mushrooms.•This is the first report of 26-carboxylated ergostane-type sterols in nature.•Sarcodonol D suppressed apoptosis in MRC-5 cells by HCoV-OC43 infection.•Sarcodonol D reduced mitochondrial dysfunction, oxidation levels, and apoptosis.

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关键词

Sarcodon imbricatus,Ergostane-type sterol,HCoV-OC43,Apoptosis,Mitochondria stress

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