Evolution of peptide YY analogs for the management of type 2 diabetes and obesity

Wang Chen, Gong Binbin,Sun Lidan,Zhou Qiang,Han Jing

Bioorganic chemistry（2023）

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摘要

•A brief pharmacological actions summary of PYY.•The effect of chemical structure modifications on the biological activity of PYY analogs.•The latest clinical progress of PYY analogs.

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关键词

Arr3,ACE,DIO,DPP-IV,Ex-4,FcRn,γ-Glu,GCGR,GIP,GLP-1,GPCR,IBS,mAb,NPY,OXM,PEG,PP,PYY,RIN,RYGB,SAR,T2DM

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