Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation.

Paresh P Kulkarni,Ravi Kumar Alluri,Matthew Godwin,Gabriel L Forbes,Alona Merkulova,Aatira Vijay,Maierdan Palihati,Suman Kundu,Young Jun-Shim,Alvin Schmaier,Michael Holinstat,Scott J Cameron,Keith R McCrae

bioRxiv : the preprint server for biology（2023）

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摘要

β2GPI deficient mice are protected from experimental arterial, venous, and microvascular thrombosis.β2GPI deficient mice display prolonged tail bleeding times and reduced PAR3-facilitated platelet activation by low concentrations of thrombin.

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