Comparative genomics and DNA methylation analysis of Pseudomonas aeruginosa clinical isolate PA3 by single-molecule real-time sequencing reveals new targets for antimicrobials.

Zijiao Li, Xiang Zhou, Danxi Liao,Ruolan Liu,Xia Zhao,Jing Wang,Qiu Zhong,Zhuo Zeng,Yizhi Peng,Yinling Tan,Zichen Yang

Frontiers in cellular and infection microbiology（2023）

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摘要

This study provided a detailed visualization and DNA methylation information of the PA3 genome and set a foundation for subsequent research into the molecular mechanism of DNA methyltransferase-controlled pathogenicity.

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关键词

pseudomonas,dna methylation analysis,antimicrobials,dna methylation,single-molecule,real-time

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