Evaluating the neuroprotective effects of progesterone receptors on experimental traumatic brain injury: The PI3K/Akt pathway.

Ladan Amirkhosravi,Mohammad Khaksari,Sedigheh Amiresmaili,Mojgan Sanjari, Parisa Khorasani,Morteza Hashemian

Brain and behavior（2023）

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摘要

According to these findings, PRs are acting as critical mediators for the neuroprotective properties of P4 on oxidative stress, pro-inflammatory cytokine levels, and neurological outcomes. PRs also play an important role in regulating the PI3K/p-Akt expression and nongenomic function of P4.

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experimental traumatic brain injury,neuroprotective effects,traumatic brain injury,progesterone receptors

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