Examining the biological pathways underlying clinical heterogeneity in Sjogren's syndrome: proteomic and network analysis.

Joe Scott Berry,Jessica Tarn,John Casement,Pierre-Marie Duret,Lauren Scott,Karl Wood, Svein-Joar Johnsen,Gunnel Nordmark,Valérie Devauchelle-Pensec,Raphaele Seror,Benjamin Fisher, Fransesca Barone,Simon J Bowman,Michele Bombardieri,Dennis Lendrem,Renaud Felten,Jacques-Eric Gottenberg,Wan-Fai Ng

Annals of the rheumatic diseases（2023）

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摘要

Our data provide clues to the pathways contributing to the glandular and non-glandular manifestations of SS and to potential therapeutic targets for different SS subtypes. In addition, our analysis highlights the need for further exploration of altered metabolism and mitochondrial dysfunction in the context of SS subtypes.

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关键词

Sjogren's Syndrome, Inflammation, Patient Reported Outcome Measures, Autoantibodies, Autoimmune Diseases

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