Activation of MAPK signaling and development of PTC in TSHR D633H knock-in mice.

Markus Eszlinger,Alexandra Stephenson,Shideh Mirhadi, Konrad Patyra, Michael F Moran,Moosa Khalil,Jukka Kero,Ralf Paschke

European thyroid journal（2023）

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摘要

The modified phosphoproteome profile of the homozygous mice in combination with human literature suggests a potential signaling pathway from constitutive TSHR signaling and cAMP activation, to the activation of ERK/MAPK signaling. This is the first time that a specific mechanism has been identified for a possible involvement of TSH signaling in thyroid carcinoma development.

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