Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context.

Justyna Czapla,Alina Drzyzga,Sybilla Matuszczak,Tomasz Cichoń,Marek Rusin,Magdalena Jarosz-Biej,Ewelina Pilny,Ryszard Smolarczyk

Frontiers in oncology（2023）

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摘要

The study provides preclinical evidence for a great influence of the TME on the outcome of applied therapy, including immune cell contribution and ICI responsiveness. We pointed the need of careful TME screening prior to antitumor treatments to achieve satisfactory results.

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关键词

STING signaling, anti-vascular therapy, immunotherapy, immune checkpoint inhibitors, the tumor microenvironment

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