Cerebrospinal fluid neurofilament light chain and total-tau as biomarkers of neurodegeneration in Alzheimer's disease and frontotemporal dementia

Guido Maria Giuffrè,Davide Quaranta,Emanuele Maria Costantini,Salvatore Citro, Noemi Martellacci, Grazia De Ninno,Maria Gabriella Vita,Valeria Guglielmi,Paolo Maria Rossini,Paolo Calabresi,Camillo Marra

Neurobiology of disease（2023）

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摘要

•NfL and t-tau reflect different pathophysiological mechanism of neurodegeneration.•The t-tau/NfL ratio distinguish MCI due to AD from FTD with high accuracy.•Episodic and semantic memory decline are related with p-tau and t-tau in prodromal AD.

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关键词

Cerebrospinal fluid biomarkers,Neurofilaments (NfL),Total tau (t-tau),Neurodegeneration,Episodic memory,Semantic memory

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