Investigation of SNP markers for the melatonin production trait in the Hu sheep with bulked segregant analysis

BMC genomics(2023)

引用 0|浏览7
暂无评分
摘要
Background As an important reproductive hormone, melatonin plays an important role in regulating the reproductive activities of sheep and other mammals. Hu sheep is a breed favoring for meat, with prolific traits. In order to explore the relationship between melatonin and reproductive function of Hu sheep, 7,694,759 SNPs were screened out through the whole genome sequencing analysis from high and low melatonin production Hu sheep. Results A total of 68,673 SNPs, involving in 1126 genes, were identified by ED association analysis. Correlation analysis of SNPs of AANAT / ASMT gene and MTNR1A / MTNR1B gene were carried out. The melatonin level of CG genotype 7,981,372 of AANAT , GA genotype 7,981,866 of ASMT and GG genotype 17,355,171 of MTNR1A were higher than the average melatonin level of 1.64 ng/mL. High melatonin Hu sheep appear to have better multiple reproductive performance. Conclusions By using different methods, three SNPs which are associated with high melatonin production trait have been identified in Hu sheep. These 3 SNPs are located in melatonin synthetase AANAT / ASMT and receptor MTNR1A , respectively. Considering the positive association between melatonin production and reproductive performance in ruminants, these three SNPs can be served as the potential molecular markers for breading Hu sheep with the desirable reproductive traits.
更多
查看译文
关键词
Hu sheep,Melatonin,Bulked segregant analysis,AANAT,ASMT,SNP
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要