Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression.

Lucas Vu,Krystine Garcia-Mansfield,Antonio Pompeiano,Jiyan An,Victoria David-Dirgo,Ritin Sharma,Vinisha Venugopal, Harkeerat Halait,Guido Marcucci,Ya-Huei Kuo,Lisa Uechi,Russell C Rockne,Patrick Pirrotte,Robert Bowser

Annals of clinical and translational neurology（2023）

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摘要

We identified pathways and protein biomarkers that distinguish rate of ALS disease progression. A mathematical model of the CSF proteome determined that the change in entropy of the proteome over time was predictive of FP versus SP.

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proteomics

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