Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice.

Rosemary M Clark,Courtney M Clark,Katherine E A Lewis,Marcus S Dyer,Jyoti A Chuckowree,Joshua A Hoyle,Catherine A Blizzard,Tracey C Dickson

Annals of clinical and translational neurology（2023）

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摘要

Taken together, these findings highlight the capacity for non-invasive brain-targeted interventions in ALS and support antagonism of NPY Y1Rs as a novel strategy to improve ALS motor function.

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关键词

motor deficits,receptor antagonism

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