FAT1 Gene Expression in Iranian Acute Lymphoid and Myeloid Leukemia Patients.

Mohammadreza Ostadali Dehagi,Shahrbano Rostami,Ahmadreza Shamshiri,Fatemeh Safari, Reza Haji Hosseini,Rick F Thorne,Ardeshir Ghavamzadeh

International journal of hematology-oncology and stem cell research（2023）

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摘要

No significant differences were found between FAT1 expression in CD34+ and CD34- leukemic samples (p> 0.3). Thus, higher FAT1 expression was evident in ALL and AML leukemia cells but this appeared unrelated to CD34 expression. This suggests in a proportion of adult acute leukemia, FAT1 expression may prove to be a suitable target for therapeutic strategies.

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