Klebsiella pneumoniae manipulates human macrophages to acquire iron.

Philipp Grubwieser,Richard Hilbe,Clemens Michael Gehrer,Manuel Grander,Natascha Brigo,Alexander Hoffmann,Markus Seifert,Sylvia Berger,Igor Theurl,Manfred Nairz,Günter Weiss

Frontiers in microbiology（2023）

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摘要

Our results suggest, that KP manipulates macrophage iron metabolism to acquire iron once confined inside the host cell and enforces intracellular bacterial persistence. This is facilitated by microbial mediated induction of TFR1 the STAT-6-IL-10 axis. Mechanistic insights into immune metabolism will provide opportunities for the development of novel antimicrobial therapies.

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关键词

macrophages, Klebsiella pneumoniae, immune metabolism, iron, transferrin, transferrin receptor, interleukin-10

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