Glove-related contact dermatitis: Diagnostic value of a repeated application test

Background Gloves are frequently the cause of occupational hand dermatitis and are responsible for irritant (ICD) and allergic contact dermatitis (ACD). The diagnosis of ACD is based on patch tests to gloves (PTg), semi-open tests to gloves (SOg), and patch tests to glove allergens (PTal). Objective The aim was to define the contribution of a glove repeated application test (GRAT) in the diagnosis strategy of glove-related contact dermatitis. Methods This retrospective study included patients with hand eczema who wore gloves and who completed a GRAT in the context of allergological explorations. It consisted of applying a piece of the glove maintained by a non-adhesive strip during 10 consecutive nights on the same area of the anterior face of the forearm. Results Ten patients were diagnosed with ACD to gloves. This diagnosis was made on positive SOg, PTg, GRAT and PTal for 2 patients, positive PTal and GRAT for 3 patients, positive SOg and GRAT for 2 patients, positive GRAT alone for 2 patients, positive PTal alone for 1 patient. The GRAT had better sensitivity than the other tests. Conclusion GRAT seems useful in the diagnostic strategy of glove contact dermatitis and could be proposed when the diagnosis of glove-related contact dermatitis is suspected. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The scientific and ethics committee of the Hospices Civils de Lyon (HCL, No. 22_5549 on 25/01/2022) gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors