Depletion of serotonin relieves concanavalin A-induced liver fibrosis in mice by inhibiting inflammation, oxidative stress, and TGF-β1/Smads signaling pathway

Qing Pang,Hao Jin, Yong Wang, Mengnan Dai,Shuangchi Liu,Yi Tan,Huichun Liu,Zheng Lu

Toxicology Letters（2021）

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摘要

•Serotonin depletion improved liver damage in LF mice.•Serotonin depletion inhibited collagen deposition in LF mice.•Serotonin depletion reduced serum and intrahepatic inflammatory cytokines in LF mice.•Serotonin depletion mitigated oxidative stress in liver tissues in LF mice.•Serotonin depletion inhabited TGF-β1/Smads signaling pathway in LF mice.

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关键词

Serotonin,Liver fibrosis,Inflammatory,Oxidative stress,Transforming growth factor β1,Smads

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