Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs.

Matthew Mannarino, Oliver Wu-Martinez,Kai Sheng,Li Li, Rodrigo Navarro-Ramirez,Peter Jarzem,Jean A Ouellet,Hosni Cherif,Lisbet Haglund

Biomolecules（2023）

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摘要

Combining o-Vanillin and RG-7112 greatly enhanced the effect of either senolytic alone. Together, these results support the potential of senolytics as a promising treatment for IVD-related low back pain.

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关键词

cellular senescence,combination therapy,intervertebral disc degeneration,low back pain,senolytics,senotherapeutics

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