Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

BLOOD(2023)

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摘要
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. While STRN3-RARA leukemia quickly relapses after ATRA treatment, they can be restrained by cepharanthine.
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