Helicobacter pylori-derived outer membrane vesicles suppress liver autophagy: A novel mechanism for H. pylori-mediated hepatic disorder

Saina Shegefti,Shahin Bolori,Ali Nabavi-Rad,Hossein Dabiri,Abbas Yadegar,Kaveh Baghaei

MICROBIAL PATHOGENESIS（2023）

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摘要

•H. pylori-derived OMVs suppressed the autophagy process in human HSCs.•H. pylori-mediated impairment of liver autophagy could lead to hepatic disorders.•OMV-carried H. pylori virulence factors might contribute to liver autophagy suppression.

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关键词

Helicobacter pylori,Outer membrane vesicles,Hepatic stellate cells,Fatty liver disease,Autophagy,MTOR

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