Feasibility of local field potential-guided programming for deep brain stimulation in Parkinson's disease: A comparison with clinical and neuro-imaging guided approaches in a randomized, controlled pilot trial

•Beta-Guided programming is an innovative approach that may streamline the programming process for PD patients with STN DBS.•While preliminary findings from our study suggest that Beta Titration may potentially mitigate STN overstimulation and enhance symptom control,•Our results demonstrate that beta-guided programming significantly reduces programming time, suggesting it could be efficiently integrated into routine clinical practice using a commercially available patient programmer.