EtHg is more toxic than MeHg to human peripheral blood mononuclear cells: Involvement of apoptotic, mitochondrial, oxidative and proliferative parameters

EtHg inhibited ETS CI-linked and consequently the ETS after 6 and 12 h of treatment. After 24 h, EtHg increased the granularity of the PBMCs, the sub-G1 phase, the indices of early apoptosis, reactive species (RS), and decreased the dehydrogenase activity and the G0-G1 phase of the cell cycle. After 48 and 72 h, EtHg increased the size and decreased the dehydrogenase activity of the PBMCs. On the other hand, the only effect induced by MeHg was the decrease in the dehydrogenase activity of PBMCs after 48 and 72 h of exposureUnlabelled Image