Levistilide A ameliorates neuroinflammation via inhibiting JAK2/STAT3 signaling for neuroprotection and cognitive improvement in scopolamine-induced Alzheimer’s disease mouse model

Haojie Ni,Yanfang Liao,Yifan Zhang, Huinian Lu, Zhiju Huang, Fengming Huang, Zhende Zhang,Yan Dong,Zihao Wang,Yujie Huang

International Immunopharmacology（2023）

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摘要

•Levistilide A found in Chinese herbs improves cognition in Alzheimer's disease.•Levistilide A reduces neuroinflammation by reversing microglia phenotype change.•Network analysis identify Levistilide A inhibits JAK2/STAT3 pathway activation.•Levistilide A inhibits the STAT3 nuclear translocation and transcription activities.•Levistilide A ameliorates neuronal damage induced by neuroinflammation.

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关键词

Alzheimer’s disease,Neuroinflammation,Microglia activation,JAK2/STAT3 pathway,Levistilide A

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