In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors (Adv. Therap. 4/2023)

Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) are key enzymes in the biosynthesis of pro-inflammatory and tumor-inducing eicosanoids. Thus, dual COX-2/5-LO inhibition may represent a promising strategy to prevent the pathogenesis of cancer and for cancer treatment. The bioisosteric replacement of the fluorophenyl moiety in RWJ-63556 by meta- or para-carborane results in potent derivatives showing dual COX-2/5-LO inhibitory and antitumor activity. This is reported by Evamarie Hey-Hawkins and co-workers in article number 2200252.