Mp58-20 overall survival after endoscopic treatment of utuc

You have accessJournal of UrologyCME1 Apr 2023MP58-20 OVERALL SURVIVAL AFTER ENDOSCOPIC TREATMENT OF UTUC Jaime Herrera Caceres, Timothy Egner, Craig Labbate, Surena Matin, Shavy Nagpal, William Huang, Jesse Persily, Marian Wettstein, Jane Choe, Jennifer Linehan, Isamu Tachibana Tachibana, Hristos Kaimakliotis, Aaron Perecman, David Canes, and Jay Raman Jaime Herrera CaceresJaime Herrera Caceres More articles by this author , Timothy EgnerTimothy Egner More articles by this author , Craig LabbateCraig Labbate More articles by this author , Surena MatinSurena Matin More articles by this author , Shavy NagpalShavy Nagpal More articles by this author , William HuangWilliam Huang More articles by this author , Jesse PersilyJesse Persily More articles by this author , Marian WettsteinMarian Wettstein More articles by this author , Jane ChoeJane Choe More articles by this author , Jennifer LinehanJennifer Linehan More articles by this author , Isamu Tachibana TachibanaIsamu Tachibana Tachibana More articles by this author , Hristos KaimakliotisHristos Kaimakliotis More articles by this author , Aaron PerecmanAaron Perecman More articles by this author , David CanesDavid Canes More articles by this author , and Jay RamanJay Raman More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003311.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The use of endoscopic techniques for the management of Upper Tract Urothelial Carcinoma (UTUC) has increased over time. Disease recurrence remains a central consideration following therapy. Here, we query a large database of endoscopic UTUC procedures to determine factors associated with overall survival. METHODS: A multi-centric database of 6 institutions was compiled to assess outcomes and characteristics of patients who underwent endoscopic management for UTUC. Cox Regression analysis determined factors associated with overall survival among this population of patients. RESULTS: A total of 392 endoscopic treatments for UTUC performed in 215 individual patients was included. Mean age was 73.5 years old, Charlson score was 5.37 and 60% were male. 61% had a smoking history, 55% had a history of bladder cancer and 4.3% had a history of cystectomy. 6% of the patients had bilateral UTUC and 57% had lesions larger than 1 cm, while 16.5% were high grade tumors. 46% of the endoscopic treatments were considered “imperative,” defined as solitary kidney or non-surgical candidates. The lesion was multifocal in 45% of the cases and cytology was positive approximately 10%. Intracavitary treatment for UTUC was used in 30% of the endoscopic treatments. Recurrence after treatment was found in 57.9%, and 14.5% underwent nephroureterectomy. 97 patients died at a mean follow-up of 33 months. Cox regression analysis found that the single independent predictor for mortality was recurrence (HR 2.27, 95% CI 1.29 – 4.00, p=0.004). CONCLUSIONS: The present information suggests that regardless of the patient characteristics, recurrence of urothelial disease is the main determinant of survival among patients with UTUC treated with endoscopic techniques. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e804 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jaime Herrera Caceres More articles by this author Timothy Egner More articles by this author Craig Labbate More articles by this author Surena Matin More articles by this author Shavy Nagpal More articles by this author William Huang More articles by this author Jesse Persily More articles by this author Marian Wettstein More articles by this author Jane Choe More articles by this author Jennifer Linehan More articles by this author Isamu Tachibana Tachibana More articles by this author Hristos Kaimakliotis More articles by this author Aaron Perecman More articles by this author David Canes More articles by this author Jay Raman More articles by this author Expand All Advertisement PDF downloadLoading ...