Fibrinogen αC domain: Its importance in physiopathology

Unlabelled BoxEssentials•The C‐terminal domain of the fibrinogen α chain (αC domain) is implicated in different severe diseases via clotting abnormalities or amyloid deposits.•Certain anomalies of the fibrinogen molecule lead to amyloid deposits in the kidney, inducing renal insufficiency.•In contrast, in Alzheimer's disease, fibrinogen is normal, but due to an inflammatory process, fibrinogen crosses into the brain and interacts with Aβ, leading to formation of pathological deposits.ACKNOWLEDGMENTSWe would like to thank Pr. Jacques Caen, who was the first to actively support our work concerning the relationship between clot structure and thrombosis. This was the starting point for all subsequent studies on Dusart Syndrome. Thank you, Pr. Caen, for giving us the opportunity to work with you.