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Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry

Burcu F. Darst,Jiayi Shen,Ravi K. Madduri,Alexis A. Rodriguez,Yukai Xiao,Xin Sheng,Edward J. Saunders,Tokhir Dadaev,Mark N. Brook,Thomas J. Hoffmann,Kenneth Muir,Peggy Wan,Loic Le Marchand,Lynne Wilkens,Ying Wang,Johanna Schleutker,Robert J. MacInnis,Cezary Cybulski,David E. Neal,Borge G. Nordestgaard,Sune F. Nielsen,Jyotsna Batra,Judith A. Clements,Henrik Gronberg,Nora Pashayan,Ruth C. Travis,Jong Y. Park,Demetrius Albanes,Stephanie Weinstein,Lorelei A. Mucci,David J. Hunter,Kathryn L. Penney,Catherine M. Tangen,Robert J. Hamilton,Marie-Elise Parent,Janet L. Stanford,Stella Koutros,Alicja Wolk,Karina D. Sorensen,William J. Blot,Edward D. Yeboah,James E. Mensah,Yong-Jie Lu,Daniel J. Schaid,Stephen N. Thibodeau,Catharine M. West,Christiane Maier,Adam S. Kibel,Geraldine Cancel-Tassin,Florence Menegaux,Esther M. John,Eli Marie Grindedal,Kay-Tee Khaw,Sue A. Ingles,Ana Vega,Barry S. Rosenstein,Manuel R. Teixeira,Manoli Kogevinas,Lisa Cannon-Albright,Chad Huff,Luc Multigner,Radka Kaneva,Robin J. Leach,Hermann Brenner,Ann W. Hsing,Rick A. Kittles,Adam B. Murphy,Christopher J. Logothetis,Susan L. Neuhausen,William B. Isaacs,Barbara Nemesure,Anselm J. Hennis,John Carpten,Hardev Pandha,Kim De Ruyck,Jianfeng Xu,Azad Razack,Soo-Hwang Teo,Lisa F. Newcomb,Jay H. Fowke,Christine Neslund-Dudas,Benjamin A. Rybicki,Marija Gamulin,Nawaid Usmani,Frank Claessens,Manuela Gago-Dominguez,Jose Esteban Castelao,Paul A. Townsend,Dana C. Crawford,Gyorgy Petrovics,Graham Casey,Monique J. Roobol, Jennifer F. Hu,Sonja I. Berndt,Stephen K. van den Eeden,Douglas F. Easton,Stephen J. Chanock,Michael B. Cook,Fredrik Wiklund,John S. Witte,Rosalind A. Eeles,Zsofia Kote-Jarai,Stephen Watya,John M. Gaziano,Amy C. Justice,David V. Conti,Christopher A. Haiman

AMERICAN JOURNAL OF HUMAN GENETICS（2023）

Cited 5|Views12
Key words
polygenic risk score,prostate cancer,health disparities,genome-wide polygenic risk score,African ancestry,genetics,risk modeling
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