Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication

Maximilian Ehrenfeld,Felicia Segeth,Klaus Mantwill,Corinna Brockhaus, Yinghui Zhao,Christian Ploner,Andreas Kolk,Jürgen E. Gschwend,Roman Nawroth,Per Sonne Holm

Journal of Virology（2023）

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摘要

E1-deleted AdV vectors are considered replication deficient and are important tools for the study of virus biology, gene therapy, and large-scale vaccine development. However, deletion of the E1 genes does not completely abolish viral DNA replication in cancer cells.

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关键词

replication,a-independent

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